Quality Director – Sterile Manufacturing (503B / Aseptic Processing)

Dallas, TX 75226

Posted: 02/03/2026 Category: Pharmacology Job Number: 166131

Job Description

Director of Quality – Sterile Manufacturing (503B / Aseptic Processing)

Dallas, TX 75226 (Onsite – Monday–Friday)
Full-Time | Direct Hire

If interested, please email your resume to LKOPASZ@ALINESTAFFING.com or 5867107959

A growing, FDA-regulated pharmaceutical manufacturing organization is seeking an experienced Director of Quality to lead the Quality Unit for its 503B Outsourcing Facility. This is a critical leadership role responsible for regulatory compliance, sterile drug manufacturing oversight, and quality systems governance within a high-visibility operation.

This position serves as the primary Subject Matter Expert (SME) for all regulatory and compliance matters related to 503B outsourcing facilities, USP <797>, USP <800>, and aseptic processing.

Sterile Manufacturing (503B / Aseptic Processing) Position Summary

The Director of Quality provides both strategic direction and hands-on leadership for sterile drug quality operations. This role oversees quality systems, batch release, compliance programs, and inspection readiness while ensuring adherence to FDA guidance, cGMP standards, and USP regulations.

 

Sterile Manufacturing (503B / Aseptic Processing) Key Responsibilities

Regulatory & Compliance Leadership

  • Serve as the technical authority for aseptic manufacturing within a 503B Outsourcing Facility
  • Ensure full compliance with FDA 503B guidance, USP <797>, USP <800>, and cGMP (21 CFR 210/211)
  • Maintain compliance with Wholesale Drug Distribution requirements
  • Interpret and apply evolving regulatory guidance to quality systems and operations

Inspection & Audit Representation

  • Act as Lead Management Representative during FDA inspections, state board audits, and third-party assessments
  • Lead inspection readiness and regulatory response strategies

Quality Operations Oversight

  • Direct Quality Operations for sterile drug manufacturing
  • Oversee batch record review, product release, and disposition for compounded sterile preparations (CSPs)
  • Ensure procedures support aseptic processing and sterile manufacturing standards

Quality Systems Management

  • Manage deviations, CAPA, change control, complaints, recalls, OOS/OOT investigations
  • Approve and oversee validation protocols, qualification reports, and SOPs with a 503B compliance focus

Risk & Continuous Improvement

  • Drive a proactive, risk-based quality culture
  • Ensure facility and process designs align with regulatory expectations

 

Sterile Manufacturing (503B / Aseptic Processing) Required Qualifications

  • Bachelor’s degree in Engineering, Life Sciences, or related field
    • Advanced degree (M.S., Pharm.D., MBA) preferred
  • 8+ years of experience in aseptic processing of sterile drugs
  • 5+ years in a quality leadership role
  • Expert knowledge of:
    • FDA Section 503B requirements and guidance
    • USP <797>, USP <800>, USP <71> Sterility Testing
    • 21 CFR Parts 210/211 (cGMP)
    • State Board of Pharmacy regulations for outsourcing facilities
  • Proven success leading FDA inspections and regulatory audits

 

Sterile Manufacturing (503B / Aseptic Processing) Key Competencies

  • Deep subject matter expertise in 503B quality systems
  • Advanced knowledge of parenteral sterile drug manufacturing
  • Strong leadership with hands-on execution capability
  • Excellent risk management and regulatory decision-making skills
  • Ability to thrive in a fast-paced, high-accountability environment

 

If interested, please email your resume to LKOPASZ@ALINESTAFFING.com or 5867107959

 

 

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